M&A of medical device companies in China

The merger and integration of Chinese medical device companies are not normal. Some people believe that the main reason for the infrequent mergers and acquisitions in the past is that the domestic medical device market has maintained a growth rate much higher than that of the international mature market, and it can maintain rapid development only by relying on organic growth. In addition, due to business habits, asset prices, and the capital market environment, it is relatively difficult to acquire high-quality domestic assets. A large number of projects seek independent listing, and the merger and integration of listed companies are even more difficult. In addition, the capital market’s recognition of M&A-style development is not high.

At present, in the overseas mergers and acquisitions and cooperation of domestic medical device companies, the “licensein + independent research and development” of medical devices is a very active business model, which also has a certain impact on the domestic medical device innovation pattern. For medical device companies, the first-mover advantage is very important. In the market environment where domestic enterprises frequently introduce overseas products, competition among enterprises will intensify in the future. After the license-in model becomes the norm, the time left for domestic enterprises to innovate in the Me-too model will be shortened, which will be a great test for the innovation strength and innovation differentiation level of enterprises. This requires that domestic medical device companies cannot stay in the imitation stage, and forward-looking thinking and strategic vision are the keys to healthy development. It is foreseeable that with the intensification of competition, some companies will fall behind in the competition, and mergers and acquisitions in the medical device industry will occur frequently in the future.

Mergers and acquisitions can help companies quickly break the ceiling and are an important path for the development and growth of medical device companies. For medical device companies, mergers and acquisitions are not only for expansion but also for survival. Intense external competition may lead to a rapid decline in market share, and mergers and acquisitions can bring about rapid breakthroughs. But not all mergers and acquisitions are successful, and there are many failures in the field of medical devices. With the advent of the era of mergers and acquisitions, consolidating the ability of internal growth is the basis for the success of corporate mergers and acquisitions.

Blood Glucose Meter for Medical Devices

      Development history and working principle of blood glucose meter
A blood glucose meter, also known as a blood glucose meter, is an electronic device that measures blood sugar levels in medical care. In 1968, (Tom Clemens) invented the first blood glucose meter. After decades of development, the blood glucose meter technology has gone through five stages of development, from the early light reflection technology to the current electrochemical method technology. Most blood glucose meters are fourth and fifth generation blood glucose meters that use electrochemical technology. At present, the mainstream blood glucose meter products all use electrochemical technology. The electrochemical method uses the principle of detecting the current signal generated in the reaction process to reflect the blood glucose level; the fourth generation blood glucose meter uses glucose oxidase as the oxidase, which is characterized by specificity. High, the technology is mature, but because the reaction process requires the participation of oxygen, the measurement results are easily affected by the blood oxygen content and cause deviations in the results; the fifth-generation blood glucose meter adopts the improved glucose dehydrogenase technology, which is no longer affected by blood. interference with other carbohydrates. Manufacturers with fifth-generation blood glucose meter technology have certain technical advantages, especially in the competition in the hospital market.
Product form and development trend of blood glucose meters
The technical iteration and product form process of blood glucose meters are mainly from the traditional invasive blood glucose to the minimally invasive blood glucose that is more common in the market now, and then to the non-invasive blood glucose that has a great opportunity to replace the existing product form in the future. Changes in testing convenience and technical principles are mostly changes in the entire industry chain, the entire blood sugar ecology, and the applicable population and application scenarios. The following lists several mainstream blood glucose product forms in the market for analysis.
1. Mobile blood glucose meter: “hardware + service” to create a closed loop of diabetes management
At present, the domestic mobile blood glucose meter should be represented by the “sugar nurse”, which monitors the patient’s diabetes data through the blood glucose meter as a monitoring terminal, and then responds to the
It is used to upload patient data to the company’s cloud, and finally provide medical services to patients through doctors in medical institutions to create sugar from monitoring to treatment to management.
Diabetes management vertical closed loop.
2. Continuous blood glucose monitoring (CGM)
At present, continuous glucose monitoring (CGM) is mainly used for continuous glucose monitoring. CGM products apply a new
Biomonitoring technology, which uses a sensor pierced under the skin to form an electrical signal when the patient’s interstitial fluid reacts with glucose in the body.
This is converted into a blood glucose reading, which is transmitted through the transmitter to a wireless receiver. Transmitters and receivers are durable devices, and sensors are disposable devices. In order to ensure measurement accuracy, current CGM products cannot be used independently and require blood readings to be corrected twice a day. CGM applications can warn patients of hypoglycemia events during the process of intensive blood sugar control, thereby reducing the incidence of hypoglycemia events. The mainstream brands in the market include Abbott’s Instantaneous Scanning Blood Glucose Meter, whose products were launched in China in 2017.
3. Non-invasive blood glucose monitoring
Non-invasive blood glucose monitoring technology has the advantages of no pain, no infection, simple measurement, and fast measurement speed, which can effectively meet the needs of diabetics to monitor blood glucose concentration in real time and frequently. According to the different monitoring objects, non-invasive blood glucose monitoring technology can be divided into near-infrared spectroscopy, microwave detection method, optical rotation method, energy metabolism conservation method, etc. These technologies are all indirect methods to measure human blood glucose concentration, which requires complex conversion. Formula to test the concentration of sugar in the blood, with a certain delay. We have noticed that non-invasive blood glucose monitoring, as a new generation of blood glucose monitoring technology, will have a subversive impact on traditional blood glucose meter manufacturers once it is commercialized. Non-invasive blood glucose monitoring can measure the blood glucose concentration of patients without test strips. In the future, breakthroughs in non-invasive blood glucose monitoring technology, enabling mass production and popularization, will have a strong impact on the traditional blood glucose meter industry chain. At present, there are dozens of brands of non-invasive blood glucose meters on the market, and few of them can get FDA and CFDA certification. The main reasons are as follows:
(1) Inaccurate test data
Non-invasive blood sugar testing is obviously non-invasive and does not collect blood, which means that this method cannot measure blood sugar by directly producing a chemical reaction with blood. The blood sugar content is calculated in an indirect way. The above process will inevitably affect blood sugar testing. Accuracy affects.
(2) high price
At present, there are very few non-invasive blood glucose detectors that have passed CE certification, let alone FDA and CFDA certification, and most of the CE certifications are Israel, the United States and other traditional powerhouses in this field, forming a monopoly in the market, and the price is also high. has been high.
(3) It is technically difficult
Non-invasive blood sugar cannot measure blood sugar through direct chemical reaction with blood. The blood sugar content is calculated by indirect methods such as optical detection. Therefore, the accuracy and stability of such products limit their development, and it is impossible to obtain high-precision non-invasive blood glucose detection products that meet the requirements of clinical diagnosis.
Prospects for blood glucose meters
The iterative upgrade cycle of technology is accelerated, and more intelligent blood glucose meters in product forms will appear
It has been less than 60 years since the birth of blood glucose meters. During this period, the detection technology of blood glucose meters has changed from optical reflection technology to electrochemical reaction technology, to body fluid detection and optical detection. While undergoing many iterations of technical principle upgrades, it is also accompanied by changes in product form, from traditional invasive testing to minimally invasive testing, and then transitioning to non-invasive testing that has not yet been used on a large scale. We can find that technology iterative upgrades faster. At the same time, the commercial application of 5G and the increasing maturity of AI technology will provide infinite possibilities for the intelligent upgrade of blood glucose meters.

Correct use of the fascia gun

The function of the fascia gun The fascia gun is to use the high-speed vibrating gun head to impact the tight body parts after the body exercise to help the muscles and soft tissues relax and recover, avoid fascia adhesion, and relieve muscle stiffness, stiffness and tightness. It can also promote blood circulation, dissipate creatine produced due to fatigue, and help relieve fatigue and soreness in the body. Using the fascia gun incorrectly will cause damage to the body, but using the fascia gun correctly will not cause harm to the body. For example, if the fascia gun is used in the joints, it is easy to cause joint damage; if it is used in the neck, chest and abdomen, armpits and other parts with thin, sensitive and concentrated internal organs, it is also easy to be injured; and the fascia gun is in It can be used for 5-10 minutes in the same position, but it will cause discomfort if used for a long time.

What is a medical device?

The definition of medical device in Chapter VIII Supplementary Provisions of the Regulations on the Supervision and Administration of Medical Devices (Order No. 650 of the State Council of the People’s Republic of China) refers to the instruments, equipment, appliances, in vitro diagnostic reagents and calibrators, materials and other materials that are directly or indirectly used in the human body. Similar or related items, including required computer software.

The use of medical devices is intended to achieve the following intended purposes:

  1. Prevention, diagnosis, treatment, monitoring and mitigation of diseases.
  2. Diagnosis, treatment, monitoring, mitigation, compensation for injury or disability.
  3. The study, substitution, modulation or support of anatomical or physiological processes.
  4. Support or maintenance of life.
  5. Pregnancy control.
  6. Provides information for medical or diagnostic purposes by examining samples from the human body.

What are the main household medical devices?

Medical devices that can be used for “home use” must also have a medical device product registration certificate. There are:
Home therapeutic equipment Far-infrared therapeutic equipment, magnetic therapy equipment, physiotherapy equipment, intermediate frequency therapeutic equipment, etc.
Household testing equipment: blood pressure detector, blood sugar detector, electronic thermometer, stethoscope, etc.
Household medical rehabilitation equipment: household oxygen generator, cervical and lumbar tractor, anti-pressure ulcer mattress, orthosis, etc.

What are the classification and characteristics of sphygmomanometers?

The mercury (mercury) sphygmomanometer is durable, stable and accurate in measuring blood pressure; it is completely dependent on human subjectivity, has poor repeatability, and its accuracy depends on the experience of clinicians. External noise interferes with the identification of “Korotkoff sounds”, which is inconvenient to carry.

The electronic sphygmomanometer does not need to master Korotkoff sound auscultation, it is small and light, easy to use, easy to master, low noise, no mercury leakage, suitable for home self-test or measurement on business trips. It has high sensitivity and poor anti-interference, and is easily affected by factors such as the subject’s body position, upper arm position, and cuff wrapping position.

The barometer type sphygmomanometer is small in size, has no liquid, is easy to carry, and has no mercury leakage problem, but it is difficult to ensure that the pressure measurement data is always accurate. It must be regularly calibrated with the mercury sphygmomanometer, and the reading is usually low.